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Akinori Nishi Selected Research

15- methyl- 8- aza- 16- oxagona- 1,3,5(10),13- tetraen- 17- one (MAOTO)

1/2022Maoto, a traditional Japanese medicine, controls acute systemic inflammation induced by polyI:C administration through noradrenergic function.
1/2021Effects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection.
2/2019Phenotyping analysis of the Japanese Kampo medicine maoto in healthy human subjects using wide-targeted plasma metabolomics.
1/2017Deconstructing the traditional Japanese medicine "Kampo": compounds, metabolites and pharmacological profile of maoto, a remedy for flu-like symptoms.

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Akinori Nishi Research Topics

Disease

7Schizophrenia (Dementia Praecox)
11/2022 - 06/2009
5Substance-Related Disorders (Drug Abuse)
12/2021 - 06/2008
4Inflammation (Inflammations)
11/2023 - 07/2013
3Infections
01/2022 - 02/2019
3Respiratory Tract Infections (Respiratory Tract Infection)
01/2022 - 09/2020
3Parkinson Disease (Parkinson's Disease)
03/2015 - 05/2010
2Non-alcoholic Fatty Liver Disease
12/2022 - 03/2020
2Alzheimer Disease (Alzheimer's Disease)
11/2022 - 07/2022
2Hypersensitivity (Allergy)
01/2022 - 06/2006
2Parkinsonian Disorders (Parkinsonism)
01/2021 - 11/2016
2Obesity
03/2020 - 01/2020
2Neurodegenerative Diseases (Neurodegenerative Disease)
03/2017 - 10/2008
2Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
11/2014 - 12/2003
2Mental Disorders (Mental Disorder)
01/2010 - 06/2008
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
11/2023
1Colitis
11/2023
1Autism Spectrum Disorder
11/2022
1Epilepsy (Aura)
11/2022
1Intellectual Disability (Idiocy)
11/2022
1Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
01/2022
1Respiratory Syncytial Virus Infections
01/2022
1Depressive Disorder (Melancholia)
01/2022
1Cholestasis
08/2021
1Fibrosis (Cirrhosis)
08/2021
1Human Influenza (Influenza)
01/2021
1Dyskinesias (Dyskinesia)
01/2021
1Common Cold
09/2020
1Body Weight (Weight, Body)
01/2017
1Dementia (Dementias)
05/2015
1Hallucinations (Hallucination)
05/2015
1Neuroblastoma
08/2009
1Bipolar Disorder (Manic Depressive Psychosis)
06/2009
1Catalepsy
11/2007
1Reperfusion Injury
09/2006

Drug/Important Bio-Agent (IBA)

12Dopamine (Intropin)FDA LinkGeneric
11/2023 - 12/2003
415- methyl- 8- aza- 16- oxagona- 1,3,5(10),13- tetraen- 17- one (MAOTO)IBA
01/2022 - 01/2017
4Dopamine D1 Receptors (Dopamine D1 Receptor)IBA
01/2021 - 08/2009
3CytokinesIBA
11/2023 - 07/2013
2LipidsIBA
12/2022 - 01/2021
2Proteins (Proteins, Gene)FDA Link
01/2022 - 07/2013
2Norepinephrine (Noradrenaline)FDA LinkGeneric
01/2022 - 05/2010
2Methylphenidate (Ritalin)FDA LinkGeneric
11/2014 - 12/2003
2Protein Isoforms (Isoforms)IBA
02/2012 - 10/2008
1Dextran SulfateIBA
11/2023
1TDO inhibitor LM10IBA
11/2023
1KynurenineIBA
11/2023
1Arachidonic Acid (Vitamin F)IBA
12/2022
1daisaikotoIBA
12/2022
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
11/2022
1CalcineurinIBA
11/2022
1RNA (Ribonucleic Acid)IBA
07/2022
1Glycoproteins (Glycoprotein)IBA
01/2022
1Antidepressive Agents (Antidepressants)IBA
01/2022
1Glutamic Acid (Glutamate)FDA Link
12/2021
1Aquaporins (Water Channels)IBA
08/2021
1sairei-toIBA
08/2021
1Plant ExtractsIBA
08/2021
1Levodopa (L Dopa)FDA LinkGeneric
01/2021
1Oxidopamine (6 Hydroxydopamine)IBA
01/2021
1Mao-toIBA
01/2021
1bofu-tsusho-sanIBA
03/2020
1Prion ProteinsIBA
02/2020
1GhrelinIBA
01/2020
1Hormones (Hormone)IBA
01/2020
1Sulfides (Thioethers)IBA
12/2019
1EnzymesIBA
12/2019
1polysulfideIBA
12/2019
1Hydrogen Sulfide (Sulfide, Hydrogen)IBA
12/2019
1Therapeutic UsesIBA
03/2017
1Toll-Like Receptor 3IBA
01/2017
1Dopamine Receptors (Dopamine Receptor)IBA
11/2016
1Cholinergic Agents (Cholinergics)IBA
11/2016
1Phosphoprotein Phosphatases (Phosphatases, Protein)IBA
11/2016
15-HT2A Serotonin Receptor (5 HT2A Receptor)IBA
05/2015
1Yi-Gan SanIBA
05/2015
1Hallucinogens (Psychedelics)IBA
05/2015
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
03/2015
1ProteomeIBA
07/2013
1NAD (NADH)IBA
07/2013
14- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA
07/2013
1NADPH Oxidases (NAD(P)H oxidase)IBA
07/2013
1Carrier Proteins (Binding Protein)IBA
07/2013
1ParvalbuminsIBA
07/2013
1ResveratrolIBA
05/2013
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
01/2010
1Nitric Oxide (Nitrogen Monoxide)FDA Link
06/2009
1Cyclic NucleotidesIBA
10/2008
1SK&F 81297IBA
11/2007
1Cocaine (Cocaine HCl)IBA
11/2007
1RacloprideIBA
11/2007
1Membrane Proteins (Integral Membrane Proteins)IBA
09/2006
1DystrophinIBA
09/2006
1Nicorandil (SG 75)IBA
09/2006

Therapy/Procedure

5Kampo Medicine (Kampo)
01/2022 - 05/2015
2Traditional Medicine (Folk Remedies)
09/2020 - 03/2020
1Intraperitoneal Injections
01/2022
1Therapeutics
01/2022
1Ligation
08/2021
1Oral Administration
01/2021
1Deep Brain Stimulation
11/2016